Protein : APP
Owner Public
URN urn:agi-llid:351
Hugo ID 620
Connectivity 1668
Name APP
Description amyloid beta (A4) precursor protein
Notes activates voltage dependent calcium channels; may induce neuronal apoptosis [RGD]
RGD ID 2139
MGI ID 88059
Cell Localization Plasma membrane
Pathway Caspases
Apoptosis
Copy of 'Apoptosis'
Apoptosis2
Group Receptors
cell adhesion
regulation of synapse structure and function
Notch signaling pathway
neuron remodeling
axonogenesis
axon midline choice point recognition
collateral sprouting in the absence of injury
neurite development
dendrite development
extracellular matrix organization and biogenesis
G2 phase of mitotic cell cycle
positive regulation of progression through mitotic cell cycle
apoptosis
induction of apoptosis
copper ion homeostasis
smooth endoplasmic reticulum calcium ion homeostasis
axon cargo transport
regulation of translation
positive regulation of transcription from RNA polymerase II promoter
mRNA polyadenylation
synaptic growth at neuromuscular junction
endocytosis
forebrain development
regulation of body size
mating behavior
suckling behavior
neuromuscular physiological process
regulation of balance
locomotory behavior
adult locomotory behavior
visual learning
extracellular region
apical part of cell
cell surface
membrane
membrane fraction
neuron projection
ciliary rootlet
axon
cytoplasm
cytoplasmic vesicle
Golgi apparatus
perinuclear region
spindle midzone
integral to membrane
integral to plasma membrane
coated pit
neuromuscular junction
binding
protein binding
heparin binding
metal ion binding
copper ion binding
iron ion binding
zinc ion binding
DNA binding
protease activator activity
endopeptidase inhibitor activity
serine-type endopeptidase inhibitor activity
GenBank ID NC_000021
NM_201414
NP_958817
NM_201413
NP_958816
NM_000484
NP_000475
NT_011512
NW_927384
AC_000064
AP001439
AP001440
AP001441
AP001442
AP001443
AY011354
AAG47389
AY919674
AAW82435
CS275872
CAJ84410
D87675
BAA22264
M24546
AAC13654
M29270
AAA51768
M33112
AAB59502
M34862
M34863
M34864
M34865
M34866
M34867
M34868
M34869
M34870
M34871
M34872
M34873
M34874
M34875
AAB59501
M34876
M34877
M34878
M34879
M37896
AAA51727
S45136
AAB23646
S60317
AAC60601
X13466
CAA31830
AB066441
BAB71958
AF282245
AAQ14327
BC004369
AAH04369
BC065523
AAH65523
BC065529
AAH65529
BE907745
BI559391
BM172428
CR618347
CR618842
M15532
AAA51564
M15533
AAA35540
M16765
AAA51722
M18734
AAA51726
M28373
AAA58727
M35675
AAA60163
S60721
AAB26263
S61380
AAB26264
S61383
AAB26265
X06981
CAA30041
X06982
CAA30042
X06989
CAA30050
Y00264
CAA68374
P05067
Q6GSC0
Q6P0P4
Q8WZ99
Q9BYY9
Q9UC33
A02759
CAA00268
NC_000082
NM_007471
NP_031497
NT_039625
NW_000108
NW_001030584
AC_000038
AC164302
AF056079
AAC63987
AF199003
AF199004
AF199005
AAF20194
AY011334
AAG47369
D10603
BAA01456
U82624
AAB40919
AK029172
AK030583
AK052448
BAC34997
AK076506
BAC36369
AK086946
AK128971
AK133639
AK147543
BAE27986
AK148439
AK159245
BAE34927
AK159352
AK159718
BAE35313
AK161854
AK161976
AK190051
AK190067
AK190928
AK191703
AK191711
AK192103
AK192320
AK192899
AK192938
AK194233
AK194558
AK194656
AK197763
AK198568
AK199923
AK200287
AK200960
AK201130
AK202486
AK202618
AK203089
AK209458
AK211859
AK213784
AK216049
AK216591
AK218128
AK218334
AY267348
AAP23169
BC005490
AAH05490
BC070409
AAH70409
M18373
AAA37139
M24397
AAA39929
U84012
AAB41502
X15210
CAA33280
X59379
O88868
P12023
Q53ZT3
NC_005110
NM_019288
NP_062161
NW_001084660
NW_047354
AC_000079
AY011335
AAG47370
L11926
AAA74458
AF513015
AAM90259
BC062082
AAH62082
P08592
Q547B7
Source Curated
LocusLink ID 351
11820
54226
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 104760
605714
Alias AAA
AD1
PN2
ABPP
APPI
CVAP
ABETA
CTFgamma
amyloid beta A4 protein
protease nexin-II
A4 amyloid protein
amyloid-beta protein
beta-amyloid peptide
cerebral vascular amyloid peptide
Adap
appican
betaAPP
AL024401
E030013M08Rik
amyloid beta (A4) precursor protein
protease nexin II
GO ID 0005507
0008201
0005506
0046872
0005515
0004867
0008270
0007219
0006915
0007155
0006878
0006897
0050905
0009986
0005905
0005576
0005887
0016020
0003677
0005488
0004866
0000085
0008344
0008088
0016199
0007409
0048669
0016358
0030198
0030900
0007626
0006378
0007617
0031175
0016322
0045931
0045944
0050885
0040014
0050803
0006445
0051563
0001967
0051124
0008542
0005794
0045177
0030424
0035253
0005737
0031410
0016021
0005624
0031594
0043005
0048471
0051233
0016504
0006917
Swiss-Prot Accession P05067
Q6GSC0
Q6P0P4
Q8WZ99
Q9BYY9
Q9UC33
O88868
P12023
Q53ZT3
P08592
Q547B7
Unigene ID Hs.642685
Mm.277585
Rn.2104