Regulation :


Effect	positive
Owner	Public
URN	urn:agi-Regulation:inout-urn:agi-go:0004704:out-urn:agi-complex:3000097::positive
Entities	NF-kappaB-inducing kinase --+> Nuclear factor NF kappa B
References	91
Connectivity	2


MedLine Reference	10085062:1065
Sentence	NIK and MEKK1 activate NF-kappaB by inducing the site-specific phosphorylation of IkappaB.
Journal	J. Biol. Chem
Journal Reference	v274 i13 p8355 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/13/8355
Source	Curated
CellLineName	HeLa


MedLine Reference	10075662:1035
Sentence	When overexpressed in cultured cells, NIK , but not a kinase-inactive mutant (NIK-KM), activates NF-kappaB ( 7 , 15 , 20 ) and JNK ( 15 , 21 ).
Journal	J. Biol. Chem
Journal Reference	v274 i12 p7724 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/12/7724
Source	Curated


MedLine Reference	10583419:1042
Sentence	Both Akt and NF-kappaB-inducing kinase (NIK) are necessary for TNF-alpha-induced activation of NF-kappaB, and Akt mediates IKKalpha phosphorylation in 293 cells ( 36 ).
Journal	Eur. J. Biochem
Journal Reference	v266 i3 p1210 (1999)
Journal Link	http://www.ejbiochem.org/cgi/content/full/266/3/1210
Organism	mouse
Source	Curated
CellLineName	293


MedLine Reference	10362687:1126
Sentence	When overexpressed, the MAPKKK protein NIK (NF-kappaB i nducing k inase) (Malinin et al. 1997 ) activates NF-kappaB but not AP-1 (Song et al. 1997 ) and may be one such downstream kinase.
Journal	Heart Circul
Journal Reference	v276 i6 pH2053 (1999)
Journal Link	http://ajpheart.physiology.org/cgi/content/full/276/6/H2053
Organism	pig
Source	Curated
CellLineName	LUC


MedLine Reference	11116146:1256
Journal	J. Biol. Chem
Journal Reference	v276 i12 p8865 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/12/8865
Source	Curated


MedLine Reference	11087727:1105
Journal	J. Biol. Chem
Journal Reference	v276 i9 p6214 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/9/6214
Organism	plant
Source	Curated
CellLineName	293


MedLine Reference	10921914:1152
Journal	J. Biol. Chem
Journal Reference	v275 i42 p32747 (2000)
Journal Link	http://www.jbc.org/cgi/content/full/275/42/32747
Source	Curated


MedLine Reference	10887201:1009
Journal	J. Biol. Chem
Journal Reference	v275 i28 p21081 (2000)
Journal Link	http://www.jbc.org/cgi/content/full/275/28/21081
Source	Curated


MedLine Reference	10764746:1324
Journal	J. Biol. Chem
Journal Reference	v275 i24 p18586 (2000)
Journal Link	http://www.jbc.org/cgi/content/full/275/24/18586
Organism	C-elegans
Source	Curated


MedLine Reference	10753878:1017
Journal	J. Biol. Chem
Journal Reference	v275 i15 p10838 (2000)
Journal Link	http://www.jbc.org/cgi/content/full/275/15/10838
Organism	plant
Source	Curated


MedLine Reference	10617615:1188
Journal	J. Biol. Chem
Journal Reference	v275 i1 p271 (2000)
Journal Link	http://www.jbc.org/cgi/content/full/275/1/271
Source	Curated
CellLineName	293


MedLine Reference	10428782:1028
Journal	J. Biol. Chem
Journal Reference	v274 i32 p22176 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/32/22176
Source	Curated


MedLine Reference	10364242:1201
Journal	J. Biol. Chem
Journal Reference	v274 i25 p17946 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/25/17946
Source	Curated
CellLineName	293T


MedLine Reference	10224059:1029
Journal	J. Biol. Chem
Journal Reference	v274 i19 p13077 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/19/13077
Organism	mouse
Source	Curated


MedLine Reference	10187861:1255
Journal	J. Biol. Chem
Journal Reference	v274 i15 p10641 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/15/10641
Source	Curated


MedLine Reference	12598905:4
Tissue	marrow
Organism	mouse
Source	Curated


MedLine Reference	12185077:1
Organism	yeast
Source	Curated


MedLine Reference	11502884:1219
Journal	Mol. Pharm
Journal Reference	v60 i3 p528 (2001)
Journal Link	http://molpharm.aspetjournals.org/cgi/content/full/60/3/528
Organism	rat
Source	Curated
CellLineName	IEC6


MedLine Reference	11585901:1138
Journal	Mol. Cell. Biol
Journal Reference	v21 i21 p7207 (2001)
Journal Link	http://mcb.asm.org/cgi/content/full/21/21/7207
Source	Curated


MedLine Reference	10490604:1174
Journal	Mol. Cell. Biol
Journal Reference	v19 i10 p6742 (1999)
Journal Link	http://mcb.asm.org/cgi/content/full/19/10/6742
Source	Curated
CellLineName	HEK 293


MedLine Reference	9625770:1100
Journal	J. Exp. Med
Journal Reference	v187 i12 p2097 (1998)
Journal Link	http://www.jem.org/cgi/content/full/187/12/2097
Organism	drosophila
Source	Curated


MedLine Reference	9830064:1031
Journal	J. Biol. Chem
Journal Reference	v273 i49 p33091 (1998)
Journal Link	http://www.jbc.org/cgi/content/full/273/49/33091
Source	Curated


MedLine Reference	9737979:1193
Journal	J. Biol. Chem
Journal Reference	v273 i39 p25185 (1998)
Journal Link	http://www.jbc.org/cgi/content/full/273/39/25185
Source	Curated


MedLine Reference	14561765:1090
Journal	J. Biol. Chem
Journal Reference	v278 i52 p52406 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/52/52406
Organism	mouse
Source	Curated
CellType	fibroblast


MedLine Reference	12748188:1119
Journal	J. Biol. Chem
Journal Reference	v278 i29 p26879 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/29/26879
Organism	mouse
Source	Curated


MedLine Reference	12540841:1344
Journal	J. Biol. Chem
Journal Reference	v278 i14 p12294 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/14/12294
Organism	mouse
Source	Curated


MedLine Reference	12419817:1043
Journal	J. Biol. Chem
Journal Reference	v278 i2 p919 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/2/919
Source	Curated


MedLine Reference	12237314:1251
Journal	J. Biol. Chem
Journal Reference	v277 i47 p44791 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/47/44791
Organism	mouse
Source	Curated


MedLine Reference	11773061:1033
Journal	J. Biol. Chem
Journal Reference	v277 i10 p7920 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/10/7920
Source	Curated


MedLine Reference	11279241:1012
Journal	J. Biol. Chem
Journal Reference	v276 i23 p20228 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/23/20228
Organism	rat
Source	Curated
CellType	myoblast
CellLineName	L6E9


MedLine Reference	11278990:1013
Journal	J. Biol. Chem
Journal Reference	v276 i19 p15854 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/19/15854
Organism	mouse
Source	Curated
CellType	macrophage
CellLineName	J774


MedLine Reference	10521444:1011
Journal	J. Biol. Chem
Journal Reference	v274 i43 p30603 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/43/30603
Source	Curated


MedLine Reference	10488062:1077
Journal	J. Biol. Chem
Journal Reference	v274 i39 p27339 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/39/27339
Organism	drosophila
Source	Curated


MedLine Reference	9990853:1120
Journal	Genes & Dev
Journal Reference	v13 i3 p284 (1999)
Journal Link	http://www.genesdev.org/cgi/content/full/13/3/284
Organism	drosophila
Source	Curated
CellLineName	293


MedLine Reference	10346818:1149
Journal	Genes & Dev
Journal Reference	v13 i10 p1297 (1999)
Journal Link	http://www.genesdev.org/cgi/content/full/13/10/1297
Source	Curated
CellLineName	HeLa


MedLine Reference	10581243:1023
Journal	EMBO
Journal Reference	v18 i23 p6694 (1999)
Journal Link	http://embojournal.npgjournals.com/cgi/content/full/18/23/6694
Source	Curated
CellType	t cell
CellLineName	EBV


MedLine Reference	10228165:1161
Journal	EMBO
Journal Reference	v18 i9 p2511 (1999)
Journal Link	http://embojournal.npgjournals.com/cgi/content/full/18/9/2511
Source	Curated


Journal	Cell
Journal Reference	v103 i2 p351 (2000)
Journal Link	http://www.cell.com/cgi/content/full/103/2/351
Source	Curated
CellType	t cell


Journal	Cell
Journal Reference	v103 i2 p351.2 (2000)
Journal Link	http://www.cell.com/cgi/content/full/103/2/351.2
Source	Curated
CellType	t cell


Journal	Cell
Journal Reference	v103 i2 p351.1 (2000)
Journal Link	http://www.cell.com/cgi/content/full/103/2/351.1
Source	Curated
CellType	t cell


Journal	Cell
Journal Reference	v91 i3 p299 (1997)
Journal Link	http://www.cell.com/cgi/content/full/91/3/299
Source	Curated


Journal	Cell
Journal Reference	v90 i2 p373 (1997)
Journal Link	http://www.cell.com/cgi/content/full/90/2/373
Source	Curated


Journal	Cell
Journal Reference	v90 i2 p373 (1997)
Journal Link	http://www.cell.com/cgi/content/full/90/2/373
Source	Curated


MedLine Reference	12055104:1035
Journal	Cell Phys
Journal Reference	v283 i1 pC347 (2002)
Journal Link	http://ajpcell.physiology.org/cgi/content/full/283/1/C347
Source	Curated
CellType	b cell


MedLine Reference	11251123:1052
Journal	Science
Journal Reference	v291 i5511 p2162 (2001)
Journal Link	http://www.sciencemag.org/cgi/content/full/291/5511/2162
Organism	mouse
Source	Curated
CellType	b cell


MedLine Reference	9520446:1027
Journal	PNAS
Journal Reference	v95 i7 p3792 (1998)
Journal Link	http://www.pnas.org/cgi/content/full/95/7/3792
Source	Curated


MedLine Reference	9275204:1033
Journal	PNAS
Journal Reference	v94 i18 p9792 (1997)
Journal Link	http://www.pnas.org/cgi/content/full/94/18/9792
Source	Curated


MedLine Reference	12133934:5
Organism	mouse
Source	Curated
CellType	t cell


MedLine Reference	10485710:5
Organism	mouse
Source	Curated


MedLine Reference	10648614:9
Organism	mouse
Source	Curated
CellLineName	PIC


MedLine Reference	9520401:3
Organism	mouse
Source	Curated


MedLine Reference	10385526:1155
Journal	J. Cell Biol
Journal Reference	v145 i7 p1471 (1999)
Journal Link	http://www.jcb.org/cgi/content/full/145/7/1471
Organism	mouse
Source	Curated
CellLineName	293T


MedLine Reference	9804849:1042
Journal	J. Biol. Chem
Journal Reference	v273 i46 p30736 (1998)
Journal Link	http://www.jbc.org/cgi/content/full/273/46/30736
Source	Curated
CellLineName	HeLa


MedLine Reference	11262403:1030
Journal	J. Biol. Chem
Journal Reference	v276 i23 p19889 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/23/19889
Source	Curated


MedLine Reference	9582383:1016
Journal	J. Biol. Chem
Journal Reference	v273 i21 p13353 (1998)
Journal Link	http://www.jbc.org/cgi/content/full/273/21/13353
Source	Curated
CellType	b cell


MedLine Reference	12968033:1318
Journal	J. Biol. Chem
Journal Reference	v278 i47 p46565 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/47/46565
Organism	rat
Source	Curated
CellType	fibroblast


MedLine Reference	12591926:1103
Journal	J. Biol. Chem
Journal Reference	v278 i17 p15429 (2003)
Journal Link	http://www.jbc.org/cgi/content/full/278/17/15429
Source	Curated


MedLine Reference	12181323:1280
Journal	J. Biol. Chem
Journal Reference	v277 i42 p39850 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/42/39850
Organism	mouse
Source	Curated


MedLine Reference	11976320:1179
Journal	J. Biol. Chem
Journal Reference	v277 i27 p24169 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/27/24169
Source	Curated
CellLineName	293


MedLine Reference	11825888:1186
Journal	J. Biol. Chem
Journal Reference	v277 i16 p13693 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/16/13693
Organism	mouse
Source	Curated


MedLine Reference	11801607:1208
Journal	J. Biol. Chem
Journal Reference	v277 i13 p10842 (2002)
Journal Link	http://www.jbc.org/cgi/content/full/277/13/10842
Source	Curated


MedLine Reference	11461927:1147
Journal	J. Biol. Chem
Journal Reference	v276 i37 p34743 (2001)
Journal Link	http://www.jbc.org/cgi/content/full/276/37/34743
Source	Curated
CellLineName	HeLa


MedLine Reference	11016939:1110
Journal	J. Biol. Chem
Journal Reference	v275 i50 p39779 (2000)
Journal Link	http://www.jbc.org/cgi/content/full/275/50/39779
Source	Curated
CellLineName	293


MedLine Reference	15725700:6
Tissue	marrow
Source	Curated
CellType	Mesenchymal Stem


MedLine Reference	15252129:6
Tissue	lymph node
Source	Curated
CellType	b cell


MedLine Reference	12639713:4
Tissue	smooth muscle
Organ	trachea
Organism	dog
Source	Curated


MedLine Reference	15212763:0
Organism	mouse
Source	Curated


MedLine Reference	15528996:2
Organism	mouse
Source	Curated


MedLine Reference	15265883:6
Organ	liver
Organism	mouse
Source	Curated


MedLine Reference	9694868:1012
Journal	J. Biol. Chem
Journal Reference	v273 i33 p21132 (1998)
Journal Link	http://www.jbc.org/cgi/content/full/273/33/21132
Source	Curated
CellType	t cell
CellLineName	TAX(+


MedLine Reference	10187770:1162
Journal	J. Biol. Chem
Journal Reference	v274 i15 p9955 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/15/9955
Organism	C-elegans
Source	Curated


MedLine Reference	10075645:1095
Journal	J. Biol. Chem
Journal Reference	v274 i12 p7611 (1999)
Journal Link	http://www.jbc.org/cgi/content/full/274/12/7611
Source	Curated


MedLine Reference	10330230:1243
Journal	Heart Circul
Journal Reference	v276 i5 pH1482 (1999)
Journal Link	http://ajpheart.physiology.org/cgi/content/full/276/5/H1482
Organism	rat
Source	Curated


MedLine Reference	12517735:1232
Journal	Renal Phys
Journal Reference	v284 i5 pF1037 (2003)
Journal Link	http://ajprenal.physiology.org/cgi/content/full/284/5/F1037
Organism	mouse
Source	Curated


MedLine Reference	14691250:1023
Tissue	lymph
Journal	PNAS
Journal Reference	v101 i1 p141 (1996)
Journal Link	http://www.pnas.org/cgi/content/full/101/1/141
Organism	mouse
Source	Curated
CellType	lymphocyte


MedLine Reference	9707608:1089
Journal	PNAS
Journal Reference	v95 i17 p10106 (1998)
Journal Link	http://www.pnas.org/cgi/content/full/95/17/10106
Source	Curated
CellLineName	293


MedLine Reference	9689078:1136
Journal	PNAS
Journal Reference	v95 i16 p9319 (1998)
Journal Link	http://www.pnas.org/cgi/content/full/95/16/9319
Source	Curated


MedLine Reference	10908663:1184
Journal	PNAS
Journal Reference	v97 i16 p9156 (2000)
Journal Link	http://www.pnas.org/cgi/content/full/97/16/9156
Source	Curated
CellLineName	293


MedLine Reference	10648602:1028
Journal	Mol. Cell. Biol
Journal Reference	v20 i4 p1170 (2000)
Journal Link	http://mcb.asm.org/cgi/content/full/20/4/1170
Source	Curated


MedLine Reference	10889159:11
Source	Curated


MedLine Reference	12853971:0
Source	Curated


MedLine Reference	12565903:0
Source	Curated


MedLine Reference	10553091:4
Source	Curated


MedLine Reference	12169272:6
Source	Curated
CellLineName	HEK 293


MedLine Reference	12645577:4
Source	Curated
CellLineName	A 549


MedLine Reference	11585057:8
Source	Curated
CellLineName	HeLa


MedLine Reference	9927690:4
Source	Curated
CellLineName	293


MedLine Reference	15215247:8
Organism	mouse
Source	Curated
CellLineName	HEK 293


MedLine Reference	12849693:3
Organism	rat
Source	Curated
CellLineName	Rat2


MedLine Reference	10962024:1169
Journal	PNAS
Journal Reference	v97 i19 p10489 (2000)
Journal Link	http://www.pnas.org/cgi/content/full/97/19/10489
Source	Curated


MedLine Reference	3502227000
Sentence	NIK is a member of the MEK kinase (MEKK) family whose overexpression results in NF-kappaB activation ( Malinin et al., 1997 ).
Journal	Cell
Journal Reference	v91 i2 p243 (1997)
Journal Link	http://www.cell.com/cgi/content/full/91/2/243
Source	Curated