ProtModification :

Mechanism phosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-llid:5595:out-urn:agi-go:0004711::positive
Entities MAPK3 --+> RPS6K
References 42
Connectivity 2
Effect positive
MedLine Reference 10982805:5
Sentence Low NaCl phosphorylated p38 kinase within 30 min and ERK1/2 kinases within 15 min without changing total MAP kinase levels.
CellLineName MMDD1
Organism Mus musculus
Source Curated
MedLine Reference 14511487:8
Sentence We report that treatment with the MAP kinase/ERK kinase inhibitor PD98059, which suppresses activation of the mitogen-activated protein kinases Erk1 and Erk2, results in increased persistence of Oct-4-expressing cells.
CellLineName ES
Organism Mus musculus
Source Curated
MedLine Reference 14715266:2
Sentence H(2)O(2) treatment stimulated phospholipase C-gamma1 (PLC-gamma1), extracellular signal-regulated kinase 1/2 (ERK1/2), and NF-kappaB signaling but inhibited p38 mitogen-activated protein kinase (MAPK) activation.
CellLineName CFU-O
Tissue marrow
Source Curated
CellType osteoblast
MedLine Reference 9039124:8
Sentence To further confirm the specificity of these results implicating the MAPK pathway, an antisense oligodeoxynucleotide (ODN) directed against the initiation translation site of rat ERK-1 and ERK-2 mRNA was used to suppress MAP kinase synthesis and function in rat VSMCs.
CellLineName RASMCs
Organism Rattus norvegicus
Tissue smooth muscle
Organ umbilical vein
Source Curated
MedLine Reference 11895866:1236
Sentence Silibinin inhibits constitutive activation of MAPK/ERK1/2 in A431 cells.
Journal Carcinogenesis
Journal Reference v23 i3 p499 (2002)
Journal Link http://carcin.oupjournals.org/cgi/content/full/23/3/499
CellLineName A431
Organism Mus musculus
Source Curated
MedLine Reference 12562867:1298
Sentence Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.
Journal Lipid Res
Journal Reference v44 i3 p584 (2003)
Journal Link http://www.jlr.org/cgi/content/full/44/3/584
Source Curated
MedLine Reference 12414792:1203
Sentence The kinetic study revealed that phosphorylation of MAPK/Erk1/2 preceded that of c-Myc (data not shown).
Journal J. Biol. Chem
Journal Reference v278 i2 p885 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/2/885
Source Curated
MedLine Reference 9395450:1225
Sentence ERK1/2 has been shown to phosphorylate and activate pp90 rsk , leading to phosphorylation of S6 protein and increased protein synthesis.
Source Curated
MedLine Reference 11448947:1226
Sentence Next, we observed that a biochemical blockade of p42/p44 MAPK activation or mRNA reduction through antisense technology blocked TGFeta1-induced transcriptional activation of furin P1 promoter and activation of p42/p44 MAPKs.
Journal J. Biol. Chem
Journal Reference v276 i36 p33986 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/36/33986
CellLineName HepG 2
Source Curated
MedLine Reference 14978035:1092
Sentence Western Blot and ImmunoprecipitationA? Total or active MAPK proteins were measured by immunoblot analysis using polyclonal antibodies that recognize total p44 (ERK1) and p42 (ERK2) MAPK or dually phosphorylated specific MAPK protein (Promega) as previously described ( 25 ).
Journal J. Biol. Chem
Journal Reference v279 i18 p18488 (2004)
Journal Link http://www.jbc.org/cgi/content/full/279/18/18488
Source Curated
MedLine Reference 15020686:1176
Journal Cell Sci
Journal Reference v117 i8 p1603 (2004)
Journal Link http://jcs.biologists.org/cgi/content/full/117/8/1603
Source Curated
MedLine Reference 7935402:9
CellLineName NIH 3T3
Organism Mus musculus
Source Curated
MedLine Reference 10336426:1017
Journal J. Biol. Chem
Journal Reference v274 i22 p15389 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/22/15389
CellLineName JB6
Organism Mus musculus
Source Curated
MedLine Reference 9724295:1213
Journal Heart Circul
Journal Reference v275 i3 pH906 (1998)
Journal Link http://ajpheart.physiology.org/cgi/content/full/275/3/H906
Organism Rattus norvegicus
Organ heart
Source Curated
CellType myocyte
MedLine Reference 12388118:1013
Journal Cell Phys
Journal Reference v284 i1 pC168 (2003)
Journal Link http://ajpcell.physiology.org/cgi/content/full/284/1/C168
Organism Rattus norvegicus
Organ eye
Source Curated
MedLine Reference 10444401:1255
Journal Cell Phys
Journal Reference v277 i2 pC253 (1999)
Journal Link http://ajpcell.physiology.org/cgi/content/full/277/2/C253
Organism Rattus norvegicus
Source Curated
MedLine Reference 15371543:1020
Journal Mol. Biol. Cell
Journal Reference v15 i12 p5583 (2004)
Journal Link http://www.molbiolcell.org/cgi/content/full/15/12/5583
CellLineName PC 12
Organism Rattus norvegicus
Organ brain
Source Curated
CellType neural
MedLine Reference 15698508:5
Organism Mus musculus
Source Curated
CellType neural
MedLine Reference 12951467:2
CellLineName J774.1
Organism Mus musculus
Source Curated
CellType macrophage
MedLine Reference 11341512:1
CellLineName VSMC
Organism Rattus norvegicus
Tissue smooth muscle
Source Curated
MedLine Reference 9552001:5
Source Curated
CellType neutrophil
MedLine Reference 2389002253
Organ brain
Source Curated
MedLine Reference 10415066:1136
Journal J. Immunol
Journal Reference v163 i3 p1611 (1999)
Journal Link http://www.jimmunol.org/cgi/content/full/163/3/1611
Source Curated
CellType eosinophil
MedLine Reference 8702807:1019
Journal J. Biol. Chem
Journal Reference v271 i34 p20608 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/34/20608
Source Curated
MedLine Reference 8557638:1014
Journal J. Biol. Chem
Journal Reference v271 i2 p1111 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/2/1111
Organism Rattus norvegicus
Source Curated
CellType myocyte
MedLine Reference 7499279:1027
Journal J. Biol. Chem
Journal Reference v270 i47 p27995 (1995)
Journal Link http://www.jbc.org/cgi/content/full/270/47/27995
Organism Mus musculus
Source Curated
MedLine Reference 15385570:1251
Journal J. Biol. Chem
Journal Reference v279 i51 p53365 (2004)
Journal Link http://www.jbc.org/cgi/content/full/279/51/53365
CellLineName 293
Organism Mus musculus
Source Curated
MedLine Reference 12087100:1017
Journal J. Biol. Chem
Journal Reference v277 i37 p33676 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/37/33676
CellLineName H4IIE
Organism Rattus norvegicus
Source Curated
MedLine Reference 11739397:1300
Journal J. Biol. Chem
Journal Reference v277 i9 p7587 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/9/7587
Organism Mus musculus
Source Curated
MedLine Reference 10625698:1036
Journal J. Biol. Chem
Journal Reference v275 i2 p1457 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/2/1457
Organism Rattus norvegicus
Organ ventricle
Source Curated
CellType myocyte
MedLine Reference 10593929:1179
Journal J. Biol. Chem
Journal Reference v274 i51 p36362 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/51/36362
Source Curated
MedLine Reference 9724043:1036
Journal Endocrinology
Journal Reference v139 i9 p3876 (1998)
Journal Link http://endo.endojournals.org/cgi/content/full/139/9/3876
Organ luteal
Source Curated
MedLine Reference 14612918:5
Source Curated
MedLine Reference 15069546:5
Source Curated
MedLine Reference 15661743:1
Source Curated
MedLine Reference 8939914:4
Source Curated
MedLine Reference 15355987:1141
Journal J. Biol. Chem
Journal Reference v279 i50 p51804 (2004)
Journal Link http://www.jbc.org/cgi/content/full/279/50/51804
Organism Rattus norvegicus
Source Curated
MedLine Reference 12930837:1261
Journal J. Biol. Chem
Journal Reference v278 i45 p43939 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/45/43939
Organism Rattus norvegicus
Tissue epithelia
Organ lung
Source Curated
MedLine Reference 11839780:1037
Journal Cell Sci
Journal Reference v115 i2 p283 (1997)
Journal Link http://jcs.biologists.org/cgi/content/full/115/2/283
CellLineName PC 12
Organism Rattus norvegicus
Source Curated
MedLine Reference 10677502:1183
Journal PNAS
Journal Reference v97 i4 p1578 (2000)
Journal Link http://www.pnas.org/cgi/content/full/97/4/1578
Organism Mus musculus
Source Curated
MedLine Reference 10655493:1157
Journal PNAS
Journal Reference v97 i3 p1113 (2000)
Journal Link http://www.pnas.org/cgi/content/full/97/3/1113
Organism Mus musculus
Source Curated
CellType chondrocyte
MedLine Reference 14576338:1040
Journal Mol. Endocrin
Journal Reference v18 i1 p86 (2004)
Journal Link http://mend.endojournals.org/cgi/content/full/18/1/86
CellLineName 293
Source Curated