Regulation :

Effect positive
Owner Public
URN urn:agi-Regulation:inout-urn:agi-llid:841:out-urn:agi-llid:840::positive
Entities CASP8 --+> CASP7
References 92
Connectivity 2
MedLine Reference 9463409:2
Sentence Affinity labeling techniques revealed a branched protease cascade in which caspase-8 activates caspase-3 and -7, and caspase-3, in turn, activates caspase-6.
CellLineName JURKAT
MedLine Reference 15661236:10
Sentence DISC staining proved that LPA inhibited Fas receptor aggregation and caspase-8 activation at the membrane, which further inhibited caspase-3 and 7 activation in the cytosol.
Organism Mus musculus
MedLine Reference 12482751:0
Sentence DNA damaging agents up-regulate levels of the Fas receptor or its ligand, resulting in recruitment of Fas-associated death domain (FADD) and autocatalytic activation of caspase-8, consequently activating the executioner caspases-3, -6, and -7.
MedLine Reference 11156424:10202
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Organism Mus musculus
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Organism Mus musculus
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MedLine Reference 10574967:10029
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MedLine Reference 14726442:10034
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Organism Rattus norvegicus
MedLine Reference 16172118:10025
Journal J. Biol. Chem
Journal Reference v280 i46 p38271
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MedLine Reference 12654726:10031
Journal Genes & Dev
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Organism Mus musculus
MedLine Reference 12121983:10180
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MedLine Reference 12960156:10231
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MedLine Reference 15994297:10031
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Organism Mus musculus
MedLine Reference 15226177:10074
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Journal Reference v104 i9 p2635
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MedLine Reference 15845651:10044
Journal Carcinogenesis
Journal Reference v26 i8 p1374
Journal Link http://carcin.oxfordjournals.org/cgi/content/full/26/8/1374
MedLine Reference 101001361:11009
Journal Cell
Journal Reference v94 i4 p491
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MedLine Reference 110003089:11022
Journal J. Cell Biol
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MedLine Reference 101001360:11039
Journal Cell
Journal Reference v94 i4 p481
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MedLine Reference 15026367:10232
Journal Cancer Res
Journal Reference v64 i6 p2229
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MedLine Reference 14742742:10027
Journal JPET
Journal Reference v309 i2 p634
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Organism Mus musculus
MedLine Reference 15208304:10113
Journal J. Biol. Chem
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MedLine Reference 14604899:10018
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Journal Reference v25 i2 p179
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MedLine Reference 15044404:10029
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MedLine Reference 11861801:10162
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MedLine Reference 12646553:10027
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MedLine Reference 11551979:10024
Journal J. Cell Biol
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MedLine Reference 12538628:10241
Journal Endocrinology
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Organism Rattus norvegicus
MedLine Reference 10722700:10034
Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/275/12/8610
MedLine Reference 14990584:10172
Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/279/20/21312
Organism Mus musculus
MedLine Reference 11289152:1045
Sentence After being activated, "initiator" caspases 8, 9, and 10 can cleave and activate "effector" caspases 3, 7, and 6 (21) .
Journal Cancer Res
Journal Reference v61 i6 p2713 (2001)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/61/6/2713
Source Curated
MedLine Reference 12460909:1028
Sentence Once activated, caspase 8 and caspase 9 cleave, and thereby activate downstream caspases, such as caspases 3 and 7 (19) .
Journal Cancer Res
Journal Reference v62 i23 p6928 (2002)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/62/23/6928
Organism rat
Source Curated
MedLine Reference 11156424:1201
Sentence It is well known that both caspase-8 and caspase-9 can activate caspase-3 and caspase-7 in response to different death signals (37 , 38) .
Journal Cancer Res
Journal Reference v60 i24 p7149 (2000)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/60/24/7149
Source Curated
MedLine Reference 11731435:1145
Sentence However, these caspase inhibitors, but not Z-FA-fmk, were able to prevent the activation of caspases 3, 7, 8, and 9 (Fig. 1 C ) .
Journal Cancer Res
Journal Reference v61 i23 p8504 (2001)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/61/23/8504
Source Curated
CellLineName JURKAT
MedLine Reference 10982793:1028
Journal J. Biol. Chem
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Journal Link http://www.jbc.org/cgi/content/full/275/50/39474
Organism mouse
Source Curated
MedLine Reference 10744739:1026
Journal J. Biol. Chem
Journal Reference v275 i14 p10484 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/14/10484
Organism C-elegans
Source Curated
MedLine Reference 10722700:1034
Journal J. Biol. Chem
Journal Reference v275 i12 p8610 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/12/8610
Source Curated
CellLineName lncap
MedLine Reference 10574967:1031
Journal J. Biol. Chem
Journal Reference v274 i49 p34924 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/49/34924
Organ paracrine
Organism bovine
Source Curated
MedLine Reference 12810573:1037
Journal Endocrinology
Journal Reference v144 i7 p3167 (1997)
Journal Link http://endo.endojournals.org/cgi/content/full/144/7/3167
Organism mouse
Source Curated
MedLine Reference 9545235:1036
Journal EMBO
Journal Reference v17 i8 p2215 (1998)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/17/8/2215
Source Curated
MedLine Reference 12881424:1013
Journal EMBO
Journal Reference v22 i15 p3898 (2003)
Journal Link http://embojournal.npgjournals.com/cgi/content/full/22/15/3898
Organism mouse
Source Curated
CellType fibroblast
Journal Cell
Journal Reference v94 i4 p481 (1998)
Journal Link http://www.cell.com/cgi/content/full/94/4/481
Source Curated
Journal Cell
Journal Reference v94 i4 p481 (1998)
Journal Link http://www.cell.com/cgi/content/full/94/4/481
Source Curated
Journal Cell
Journal Reference v94 i3 p325 (1998)
Journal Link http://www.cell.com/cgi/content/full/94/3/325
Source Curated
CellType t cell
MedLine Reference 12615723:1029
Journal Cancer Res
Journal Reference v63 i5 p1059 (2003)
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/63/5/1059
Organism mouse
Source Curated
MedLine Reference 11160328:1194
Journal J. Immunol
Journal Reference v166 i4 p2651 (2001)
Journal Link http://www.jimmunol.org/cgi/content/full/166/4/2651
Organism drosophila
Source Curated
CellLineName CHO
MedLine Reference 10528193:1045
Journal J. Immunol
Journal Reference v163 i9 p4909 (1999)
Journal Link http://www.jimmunol.org/cgi/content/full/163/9/4909
Organism mouse
Source Curated
CellType hepatocyte
MedLine Reference 9463409:1007
Journal J. Exp. Med
Journal Reference v187 i4 p587 (1998)
Journal Link http://www.jem.org/cgi/content/full/187/4/587
Source Curated
CellLineName JURKAT
Tissue glia
Journal J. Cell Biol
Journal Reference v163 i5 p987 (2003)
Journal Link http://www.jcb.org/cgi/content/full/163/5/987
Source Curated
CellLineName MLK
MedLine Reference 12960156:1231
Tissue hematological
Journal J. Biol. Chem
Journal Reference v278 i46 p45406 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/46/45406
Organ breast
Source Curated
MedLine Reference 12724324:1036
Journal J. Biol. Chem
Journal Reference v278 i29 p26517 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/29/26517
Organism mouse
Source Curated
CellType macrophage
MedLine Reference 12702723:1031
Journal J. Biol. Chem
Journal Reference v278 i26 p24003 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/26/24003
Source Curated
MedLine Reference 12646553:1027
Journal J. Biol. Chem
Journal Reference v278 i20 p18265 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/20/18265
Organism horse
Source Curated
MedLine Reference 12482751:1016
Journal J. Biol. Chem
Journal Reference v278 i10 p8531 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/10/8531
Source Curated
CellType keratinocyte
MedLine Reference 12446713:1169
Journal J. Biol. Chem
Journal Reference v278 i6 p4145 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/6/4145
Source Curated
MedLine Reference 12397080:1034
Journal J. Biol. Chem
Journal Reference v277 i51 p49644 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/51/49644
Organism drosophila
Source Curated
MedLine Reference 12121983:1179
Journal J. Biol. Chem
Journal Reference v277 i37 p33968 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/37/33968
Source Curated
MedLine Reference 12097334:1041
Journal J. Biol. Chem
Journal Reference v277 i37 p34295 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/37/34295
Organism rat
Source Curated
MedLine Reference 11514566:1041
Journal J. Biol. Chem
Journal Reference v276 i42 p38748 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/42/38748
Organism plant
Source Curated
MedLine Reference 11479302:1021
Journal J. Biol. Chem
Journal Reference v276 i39 p36530 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/39/36530
Organism mouse
Source Curated
MedLine Reference 11278624:1044
Journal J. Biol. Chem
Journal Reference v276 i15 p12140 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/15/12140
Organ liver
Organism mouse
Source Curated
MedLine Reference 10469173:1
Organism mouse
Source Curated
MedLine Reference 12481422:1024
Journal Mol. Cancer Ther
Journal Reference v1 i12 p999 (2002)
Journal Link http://mct.aacrjournals.org/cgi/content/full/1/12/999
Organism mouse
Source Curated
MedLine Reference 12481414:1203
Journal Mol. Cancer Ther
Journal Reference v1 i11 p929 (2002)
Journal Link http://mct.aacrjournals.org/cgi/content/full/1/11/929
Organism mouse
Source Curated
MedLine Reference 10946276:1323
Journal J. Immunol
Journal Reference v165 i5 p2500 (2000)
Journal Link http://www.jimmunol.org/cgi/content/full/165/5/2500
Source Curated
CellLineName BL41
MedLine Reference 11551979:1024
Journal J. Cell Biol
Journal Reference v154 i6 p1111 (2001)
Journal Link http://www.jcb.org/cgi/content/full/154/6/1111
Source Curated
MedLine Reference 10085120:1223
Journal J. Biol. Chem
Journal Reference v274 i13 p8788 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/13/8788
Source Curated
MedLine Reference 12824163:1297
Journal J. Biol. Chem
Journal Reference v278 i36 p34042 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/36/34042
Source Curated
MedLine Reference 11016947:1040
Journal J. Biol. Chem
Journal Reference v275 i51 p40620 (2000)
Journal Link http://www.jbc.org/cgi/content/full/275/51/40620
Organism rat
Source Curated
CellLineName K 562
MedLine Reference 8962078:1143
Journal PNAS
Journal Reference v93 i25 p14486 (1996)
Journal Link http://www.pnas.org/cgi/content/full/93/25/14486
Source Curated
MedLine Reference 11723234:1024
Journal Mol. Pharm
Journal Reference v60 i6 p1268 (2001)
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/60/6/1268
Organism rat
Source Curated
MedLine Reference 12492112:1022
Tissue endothelial
Journal Mol. Cancer Ther
Journal Reference v1 i10 p795 (2002)
Journal Link http://mct.aacrjournals.org/cgi/content/full/1/10/795
Organism bovine
Source Curated
MedLine Reference 11714870:1030
Journal JPET
Journal Reference v299 i3 p866 (2001)
Journal Link http://jpet.aspetjournals.org/cgi/content/full/299/3/866
Organism mouse
Source Curated
CellType hepatocyte
MedLine Reference 12794135:1036
Journal J. Immunol
Journal Reference v170 i12 p6065 (2003)
Journal Link http://www.jimmunol.org/cgi/content/full/170/12/6065
Organism mouse
Source Curated
CellType b cell
MedLine Reference 12496390:1034
Journal J. Immunol
Journal Reference v170 i1 p114 (2003)
Journal Link http://www.jimmunol.org/cgi/content/full/170/1/114
Organ paracrine
Source Curated