Regulation :

Effect positive
Owner Public
URN urn:agi-Regulation:inout-urn:agi-llid:351:out-urn:agi-cellproc:apoptosis::positive
Entities APP --+> apoptosis
References 388
Connectivity 2
MedLine Reference 9890971:5
Sentence The ability of beta-amyloid (Abeta) to induce apoptosis in these cells was assessed.
Organism Rattus norvegicus
MedLine Reference 16714209:1
Sentence Abeta(1-40) decreased the apoptotic rate of neutrophils.
CellType neutrophil
MedLine Reference 10662829:8
Sentence The results indicate that caspase-2 is necessary for Abeta(1-42)-induced apoptosis in vitro.
Organism Mus musculus
MedLine Reference 11733013:10135
Journal Eur. J. Biochem
Journal Reference v268 i23 p6182
Journal Link http://www.ejbiochem.org/cgi/content/full/268/23/6182
MedLine Reference 14576165:10018
Journal J. Biol. Chem
Journal Reference v279 i3 p1585
Journal Link http://www.jbc.org/cgi/content/full/279/3/1585
MedLine Reference 11069947:10236
Organism Mus musculus
MedLine Reference 9151738:10229
Organism Rattus norvegicus
MedLine Reference 16407539:10157
Organism Mus musculus
MedLine Reference 12730216:10118
Journal J. Biol. Chem
Journal Reference v278 i30 p28294
Journal Link http://www.jbc.org/cgi/content/full/278/30/28294
Organism Rattus norvegicus
MedLine Reference 11459814:10172
Journal Endocrinology
Journal Reference v142 i8 p3649
Journal Link http://endo.endojournals.org/cgi/content/full/142/8/3649
Organism Mus musculus
MedLine Reference 15028759:10329
Organism Rattus norvegicus
MedLine Reference 15356202:10231
MedLine Reference 15659604:10266
Organism Mus musculus
MedLine Reference 15604281:10335
Journal Cancer Res
Journal Reference v64 i24 p9115
Journal Link http://cancerres.aacrjournals.org/cgi/content/full/64/24/9115
Organism Mus musculus
MedLine Reference 12228224:10032
Journal J. Biol. Chem
Journal Reference v277 i47 p44701
Journal Link http://www.jbc.org/cgi/content/full/277/47/44701
MedLine Reference 16354912:10352
Organism Mus musculus
MedLine Reference 14985447:10305
Organism Mus musculus
MedLine Reference 15720400:10281
Journal Eur. J. Biochem
Journal Reference v272 i5 p1265
Journal Link http://content.febsjournal.org/cgi/content/full/272/5/1265
MedLine Reference 15710623:10226
Journal J. Biol. Chem
Journal Reference v280 i18 p18179
Journal Link http://www.jbc.org/cgi/content/full/280/18/18179
Organism Rattus norvegicus
MedLine Reference 14625087:0
Organ brain
MedLine Reference 14535955:6
Organism Mus musculus
MedLine Reference 15955457:9
MedLine Reference 12684095:7
Organism Rattus norvegicus
MedLine Reference 8922409:1
CellType neural
MedLine Reference 10863547:1
MedLine Reference 12480183:3
Organism Rattus norvegicus
MedLine Reference 12899398:2
MedLine Reference 11422442:8
MedLine Reference 11912196:4
Organism Mus musculus
MedLine Reference 12670307:0
Organism Rattus norvegicus
MedLine Reference 10377346:1
Organism Rattus norvegicus
MedLine Reference 10574364:1
Organism Rattus norvegicus
MedLine Reference 131103173:11299
MedLine Reference 131103288:11154
MedLine Reference 131103528:11391
MedLine Reference 131103300:11144
MedLine Reference 131102171:11234
MedLine Reference 131102340:11233
MedLine Reference 131101350:11223
MedLine Reference 131103312:11195
MedLine Reference 131101374:11198
MedLine Reference 131101424:11272
MedLine Reference 110002953:11091
Journal J. Cell Biol
Journal Reference v163 i1 p27
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MedLine Reference 131101311:11290
MedLine Reference 11717357:10245
Organism Mus musculus
MedLine Reference 12869627:10172
Journal Mol. Pharm
Journal Reference v64 i2 p228
Journal Link http://molpharm.aspetjournals.org/cgi/content/full/64/2/228
Organism Mus musculus
MedLine Reference 15054100:10027
Journal J. Biol. Chem
Journal Reference v279 i24 p25511
Journal Link http://www.jbc.org/cgi/content/full/279/24/25511
Organism Mus musculus
MedLine Reference 15192112:10307
Journal J. Biol. Chem
Journal Reference v279 i34 p35903
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Organism Rattus norvegicus
MedLine Reference 9185546:4
Organism Rattus norvegicus
MedLine Reference 9256500:3
Organism Mus musculus
CellType neural
MedLine Reference 12032152:5
MedLine Reference 16721663:3
MedLine Reference 12655298:4
Organism Mus musculus
MedLine Reference 11744168:9
Organism Rattus norvegicus
MedLine Reference 12545856:2
CellType neural
MedLine Reference 9696064:4
Organism Rattus norvegicus
MedLine Reference 10527810:4
Organism Rattus norvegicus
MedLine Reference 9305632:2
CellLineName NK1+
MedLine Reference 11042363:3
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CellLineName PC 12
MedLine Reference 11358479:5
Organism Mus musculus
CellType myotube
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MedLine Reference 16184608:5
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MedLine Reference 12472467:2
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MedLine Reference 8599933:4
MedLine Reference 131102401:11109
MedLine Reference 131102505:11419
MedLine Reference 106100493:11025
Journal EMBO
Journal Reference v24 i1 p7600441
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MedLine Reference 131103600:11139
MedLine Reference 131103112:11286
MedLine Reference 131103458:11062
MedLine Reference 131100811:11168
MedLine Reference 131103371:11278
MedLine Reference 131102980:11300
MedLine Reference 131102914:11231
MedLine Reference 131102454:11293
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MedLine Reference 131101145:11277
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MedLine Reference 16725131:0
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MedLine Reference 11102478:3
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Organ hippocampal
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Organism Mus musculus
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Tissue cortex
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Organism Mus musculus
MedLine Reference 11861655:5
Tissue cortex
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Organism Rattus norvegicus
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Journal Cell
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MedLine Reference 131101726:11368
MedLine Reference 106100212:11319
Journal EMBO
Journal Reference v23 i11 p7600212
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MedLine Reference 131103924:11305
MedLine Reference 131101546:11156
MedLine Reference 131101740:11232
MedLine Reference 131102813:11638
MedLine Reference 131102191:11221
MedLine Reference 131102084:11352
MedLine Reference 131102867:11281
MedLine Reference 131101530:11079
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Organism Rattus norvegicus
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MedLine Reference 16669633:0
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Journal J. Cell Biol
Journal Reference v163 i1 p11
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MedLine Reference 131100986:11017
MedLine Reference 131101284:11390
MedLine Reference 131100060:11163
MedLine Reference 131102938:11348
MedLine Reference 131101589:11213
MedLine Reference 131101686:11235
MedLine Reference 131101832:11206
MedLine Reference 131102147:11170
MedLine Reference 131102283:11179
MedLine Reference 131102298:11089
MedLine Reference 106100093:11212
Journal EMBO
Journal Reference v23 i4 p7600049
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MedLine Reference 131102174:11018
MedLine Reference 131103053:11451
MedLine Reference 101001773:11132
Journal Cell
Journal Reference v97 i3 p395.1
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MedLine Reference 12527478:1
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MedLine Reference 131102462:11332
MedLine Reference 131103058:11073
MedLine Reference 131100914:11254
MedLine Reference 131100857:11193
MedLine Reference 131100468:11148
MedLine Reference 131101729:11105
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Journal EMBO
Journal Reference v24 i9 p7600650
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