Protein : FOXO3A


Owner	Public
URN	urn:agi-llid:2309
Hugo ID	3821
Connectivity	326
Name	FOXO3A
Description	forkhead box O3a (predicted)
Notes	This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.


RGD ID	1309196


MGI ID	1890081


Cell Localization	Nucleus


Pathway	Insulin Receptor Signaling
	ACH-R in apoptosis
	AKT signaling
	PTEN signaling
	TNFRSF6 -> FOXO3A signaling pathway
	NTRKs -> FOXO3A signaling pathway
	IL7R -> FOXO3A signaling pathway
	INSR -> FOXO3A signaling pathway
	GFRs -> FOXO3A signaling pathway
	ICAM2 -> FOXO3A signaling pathway
	AKT signaling2
	ACH-R in apoptosis'-2
	tshirt 'Insulin Receptor Signaling' 3


Group	Transcription factors
	oocyte maturation
	positive regulation of erythrocyte differentiation
	transport
	apoptosis
	induction of apoptosis
	transcription
	positive regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	transcription from RNA polymerase II promoter
	ovulation (sensu Mammalia)
	antral ovarian follicle growth
	initiation of primordial ovarian follicle growth
	glucose homeostasis
	response to DNA damage stimulus
	membrane
	membrane fraction
	cytoplasm
	nucleus
	DNA binding
	sequence-specific DNA binding
	transcription factor activity
	transcriptional activator activity
	sugar porter activity
	glucose transporter activity


Source	Curated


OMIM ID	602681


Alias	AF6q21
	FKHRL1
	FKHRL1P2
	MGC12739
	MGC31925
	DKFZp781A0677
	forkhead box O3A
	forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1
	forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
	Fkhr2
	Foxo3
	C76856
	1110048B16Rik
	2010203A17Rik
	forkhead protein FKHR2
	forkhead box O3a (predicted)