ProtModification :

Mechanism phosphorylation
Owner Public
URN urn:agi-ProtModification:inout-urn:agi-llid:207:out-urn:agi-go:0008385::positive
Entities AKT1 --+> IkappaB kinase
References 15
Connectivity 2
Effect positive
MedLine Reference 11724787:1030
Sentence Protein kinase B (PKB/Akt ) has been shown to phosphorylate and activate IkappaB kinase ( 8 , 9 ), which in turn phosphorylates IkappaB.
Journal J. Biol. Chem
Journal Reference v277 i5 p3109 (2002)
Journal Link http://www.jbc.org/cgi/content/full/277/5/3109
Organism mouse
Source Curated
CellType macrophage
MedLine Reference 10995457:1019
Sentence Akt has also been shown to phosphorylate IkappaB kinase and up-regulate its kinase activity, which results in promotion of NF-kappaB-mediated inhibition of apoptosis ( 16 , 17 ).
Journal PNAS
Journal Reference v97 i20 p10832 (2000)
Journal Link http://www.pnas.org/cgi/content/full/97/20/10832
Source Curated
MedLine Reference 11123379:1199
Sentence Activation of Akt phosphorylates IkappaB kinase-alpha at threonine 23, which in turn phosphorylates IkappaB-alpha on serine 32 and 36, leading to degradation of the latter and dissociation of NF-kappaB from the inhibitory complex, allowing NF-kappaB to translocate into the nucleus (Israel, 2000 ).
Journal JPET
Journal Reference v296 i1 p181 (2001)
Journal Link http://jpet.aspetjournals.org/cgi/content/full/296/1/181
Organism plant
Source Curated
MedLine Reference 11416147:1390
Sentence AKT plays an important role in mediating antiapoptotic activities of growth factors and appears to do so in part by phosphorylating and affecting the activities of a number of proapoptotic proteins, including caspase 9, BAD, IkappaB kinase, GSK3eta, and FKHR ( 16 ; reviewed in references 33 to 35 ).
Journal Mol. Cell. Biol
Journal Reference v21 i14 p4713 (2001)
Journal Link http://mcb.asm.org/cgi/content/full/21/14/4713
Organism rat
Source Curated
MedLine Reference 11486019:1014
Sentence PKB can also cause stimulation of NF-kappaB activity by up-regulating IkappaB degradation via phosphorylation of IkappaB Kinase and by affecting NF-kappaB itself ( 29 , 31 , 33 , 43 , 52 ), thereby allowing the transcription of genes involved in promoting survival, such as the bcl-2 homologue bfl-1 ( 78 ).
Journal Mol. Cell. Biol
Journal Reference v21 i17 p5797 (2001)
Journal Link http://mcb.asm.org/cgi/content/full/21/17/5797
Organism mouse
Source Curated
CellType t cell
MedLine Reference 15113757:7
Organism mouse
Tissue marrow
Source Curated
MedLine Reference 10485711:5
Organism mouse
Source Curated
MedLine Reference 10583419:1357
Journal Eur. J. Biochem
Journal Reference v266 i3 p1210 (1999)
Journal Link http://www.ejbiochem.org/cgi/content/full/266/3/1210
Organism mouse
Source Curated
CellType hepatocyte
MedLine Reference 11134526:1186
Journal PNAS
Journal Reference v98 i1 p247 (2001)
Journal Link http://www.pnas.org/cgi/content/full/98/1/247
CellLineName sk-lms I
Organism mouse
Tissue smooth muscle
Source Curated
MedLine Reference 12589056:1150
Journal Mol. Biol. Cell
Journal Reference v14 i2 p585 (2003)
Journal Link http://www.molbiolcell.org/cgi/content/full/14/2/585
Source Curated
MedLine Reference 12871932:1261
Journal J. Biol. Chem
Journal Reference v278 i41 p39583 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/41/39583
Organism mouse
Tissue egg
Source Curated
CellType hepatocyte
MedLine Reference 11571285:1267
Journal J. Biol. Chem
Journal Reference v276 i47 p43597 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/47/43597
CellLineName Vero
Organism mouse
Source Curated
MedLine Reference 11425860:1248
Journal J. Biol. Chem
Journal Reference v276 i34 p31738 (2001)
Journal Link http://www.jbc.org/cgi/content/full/276/34/31738
Organism mouse
Source Curated
MedLine Reference 11705740:1357
Journal Gastr. Liver Phys
Journal Reference v281 i6 pG1357.htm (2001)
Journal Link http://ajpgi.physiology.org/cgi/content/full/281/6/G1357.
Organism mouse
Source Curated
CellType hepatocyte
MedLine Reference 12154067:1226
Journal Cell Sci
Journal Reference v115 i17 p3357 (1997)
Journal Link http://jcs.biologists.org/cgi/content/full/115/17/3357
CellLineName J774
Source Curated
CellType macrophage