Binding :

Connectivity 2
Owner Public
URN urn:agi-Binding:inout-urn:agi-protfc:growth%20factor%20receptor:inout-urn:agi-complex:3000112:
Entities growth factor receptor ---- Phosphatidylinositol 3-kinase
References 7
MedLine Reference 14731956:0
Sentence Phosphatidylinositol (PI) 3-kinase associates in signal-transducing complexes with activated growth factor receptors and other protein tyrosine kinases.
Organism yeast
Source Curated
MedLine Reference 7607321:3
Sentence As PI 3-kinase binds to activated growth factor receptors our data suggest that receptor activation can be coupled to receptor internalisation (down regulation) by localising PI 3-kinase stimulation of endocytosis.
Organ kidney
Organism horse
Source Curated
MedLine Reference 9361008:1303
Sentence In vivo , this may be achieved via direct association of PI3K with growth factor receptors, and PI3K has been shown to bind directly to the activated PDGF receptor ( 75 ).
Journal J. Biol. Chem
Journal Reference v272 i46 p29281 (1997)
Journal Link http://www.jbc.org/cgi/content/full/272/46/29281
Organism mouse
Source Curated
CellLineName Ba/F3
MedLine Reference 8662856:1238
Sentence The p110/p85 PtdIns 3-kinase interacts with activated tyrosine kinase growth factor receptors, and both p85 and p110 are subsequently phosphorylated on tyrosine (reviewed in Stephens et al. (1993) ).
Journal J. Biol. Chem
Journal Reference v271 i23 p13892 (1996)
Journal Link http://www.jbc.org/cgi/content/full/271/23/13892
Organism drosophila
Source Curated
MedLine Reference 10187851:1018
Sentence Growth factors activate PI 3-kinase, and p85 subunit of PI 3-kinase associates with specific phosphotyrosine either on the cytoplasmic domain of growth factor receptors or on receptor-associated adaptor proteins.
Journal J. Biol. Chem
Journal Reference v274 i15 p10566 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/15/10566
Source Curated
CellLineName T98 G
MedLine Reference 10488142:1026
Tissue hematological
CellType basophil
Journal J. Biol. Chem
Journal Reference v274 i39 p27943 (1999)
Journal Link http://www.jbc.org/cgi/content/full/274/39/27943
Source Curated
MedLine Reference 9571250:1209
Journal Mol. Biol. Cell
Journal Reference v9 i5 p1209 (1998)
Journal Link http://www.molbiolcell.org/cgi/content/full/9/5/1209
Organism rat
Source Curated