Binding :

Connectivity 2
Owner Public
URN urn:agi-Binding:inout-urn:agi-protfc:14-3-3:inout-urn:agi-llid:2308:
Entities 14-3-3 ---- FOXO1A
References 11
MedLine Reference 14664696:8
Sentence Phosphorylated FOXO1 binds 14-3-3 proteins, and co-precipitation studies with tagged proteins indicate that 14-3-3 binding involves co-operative interactions with both Thr-24 and Ser-256.
MedLine Reference 11237865:6
Sentence Our results indicated that the interaction of FKHR with 14-3-3 proteins was not required for IGF-1-stimulated exclusion of FKHR from the nucleus.
CellLineName HEK 293
MedLine Reference 14578160:10128
Sentence Phosphorylation of Thr24 has been suggested to induce interaction of FKHR with 14-3-3 proteins ( 4 , 73 ).
Journal Carcinogenesis
Journal Reference v25 i2 p241
Journal Link http://carcin.oxfordjournals.org/cgi/content/full/25/2/241
MedLine Reference 131103894:11136
MedLine Reference 15070827:10240
Journal Biology of reproduction
Journal Reference v71 i2 p629
Journal Link http://www.biolreprod.org/cgi/content/full/71/2/629
MedLine Reference 12456685:10248
Journal J. Biol. Chem
Journal Reference v278 i7 p5242
Journal Link http://www.jbc.org/cgi/content/full/278/7/5242
MedLine Reference 14504291:10304
Journal J. Biol. Chem
Journal Reference v278 i48 p48453
Journal Link http://www.jbc.org/cgi/content/full/278/48/48453
Organism Mus musculus
MedLine Reference 16172130:10322
Journal J. Biol. Chem
Journal Reference v280 i46 p38276
Journal Link http://www.jbc.org/cgi/content/full/280/46/38276
MedLine Reference 14565960:10255
Journal J. Biol. Chem
Journal Reference v279 i1 p133
Journal Link http://www.jbc.org/cgi/content/full/279/1/133
Organism Rattus norvegicus
MedLine Reference 14504291:1306
Sentence This promotes the interaction between Foxo1 and 14-3-3, thereby inhibiting translocation of Foxo1 to nucleus and transcription of proapoptotic factors ( 32 , 33 ).
Journal J. Biol. Chem
Journal Reference v278 i48 p48453 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/48/48453
Organism mouse
Source Curated
MedLine Reference 12456685:1248
Sentence Phosphorylation of FKHR by Akt on Thr24, Ser256, and Ser319 was reported to attenuate its nuclear import possibly by binding of FKHR to 14-3-3 proteins ( 9 , 12 , 27 ).
Journal J. Biol. Chem
Journal Reference v278 i7 p5242 (2003)
Journal Link http://www.jbc.org/cgi/content/full/278/7/5242
Source Curated
CellLineName HepG 2